Novel methods for the medical treatment and/or inhibition of the development of breast cancer, hypercholesterolemia, hyperlipidemia or atherosclerosis in susceptible warmblooded animals including humans involving administration of selective estrogen receptor modulator and an amount of a sex steroid precursor selected from the group consisting of dehydroepiandrosterone, dehydroepiandrosterone sulfate, androst-5-ene-3²,17²-diol, and compounds converted in vivo to one of the foregoing precursors. Further administration of bisphosphonates in combination with selective estrogen receptor modulators and/or sex steroid precursors is disclosed. Pharmaceutical compositions for delivery of active ingredients and kits useful to the invention are disclosed.用以於包括人類之易罹病的溫血動物中醫藥治療及/或抑制骨質疏鬆症、乳癌、高血膽固醇、高血脂或動脈粥樣硬化之發展的新方法，其包括投予特別是具有下列通式結構之化合物的選擇性雌激素受體調節劑：及一數量之選自下列全中的性類固醇前驅物：去氫異雄酮、去氫異雄酮硫酸鹽、雄甾－5－烯－3β,17β－二醇以及在活體內可被轉換成任一前述前驅物之化合物。進一步揭露雙膦酸鹽與選擇性雌激素受體調節劑及/或性類固醇前驅物之合併施藥以用於醫藥治療及/或抑制骨質疏鬆症之發展。亦揭露適用於本發明之用以輸送活性成分之藥學組成物與套組。
