A system and apparatus comprising a multisensor guidewire for use in interventional cardiology, e.g., Transcatheter Valve Therapies (TVT), comprises a plurality of optical sensors for direct measurement of cardiovascular parameters, e.g. transvalvular blood pressure gradients. The guidewire has flexibility and stiffness characteristics for use as a support guidewire for TVT, e.g. for Transcatheter Aortic Valve Implantation (TAVI), comprises multiple optical pressure sensors and respective optical fibers, and a pre-formed three-dimensional flexible tip, e.g. in the form of a helix. The three-dimensional pre-formed tip is configured to assist with anchoring the guidewire within one of the ventricles and atria of the heart, or within the pulmonary artery or aorta, during interventional cardiology procedures.
