Provided herein are Notch1 fusion proteins. These fusion proteins contain an extracellular domain of a human Notch1 receptor protein and an Fc portion of an antibody bound thereto. The extracellular domain (ECD) of the human Notch1 receptor protein commences with an amino acid present at the N-terminus of EGF like repeat 10 and extends at least through a C-terminal amino acid of EGF like repeat 23. The N-terminal portion of the ECD of the human Notch1 receptor protein may extend to a C-terminal amino acid of EGF like repeat 24 or may extend to a C-terminal amino acid of EGF like repeat 36. Compositions of these fusion proteins are also provided. Also provided are methods of treating age-related macular degeneration (AMD), diabetic retinopathy and cancer using the fusion proteins described herein.本發明提供Notch1融合蛋白。該等融合蛋白含有人類Notch1受體蛋白之細胞外結構域及與其結合之抗體之Fc部分。該人類Notch1受體蛋白之該細胞外結構域(ECD)以存在於EGF樣重複序列10之N端之胺基酸開始，並至少延伸至EGF樣重複序列23之C端胺基酸。該人類Notch1受體蛋白之該ECD之N端部分可延伸至EGF樣重複序列24之C端胺基酸，或可延伸至EGF樣重複序列36之C端胺基酸。亦提供該等融合蛋白之組合物。亦提供使用本文所述之該等融合蛋白治療老年性黃斑病變(AMD)、糖尿病視網膜病變及癌症之方法。
