MATTHEW JOSEPH BIRCHMEIER,DENIS BILLEN,RONALD J. VANDERROEST
申请号：
ARP130103110
公开号：
AR092409A1
申请日:
2013.08.30
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Claim 1: a Crystalline form a of 1 - (5 - (5 - (3,5 - Dichloro - 4-fluorophenyl) - 5 - (trifluoromethyl) - 4.5 - dihidroisoxazol - 3 - yl) - 3h azetidin - 3.1 - spiro [isobenzofuran] - 1 - il) - 2 - (methylsulfonyl) ethanone. Which exhibits at least one of the following properties: (a) a diffraction pattern It has characteristic x-ray Peaks (0,2 u00ba 2Q (expressed in degrees) at about 17, 18,83 and 20,07； (b) a pattern of x-ray diffraction Peaks characteristic is expressed in degrees (0,2 u00ba approximately 2Q) 17,18 and 20,07 players, and also comprises at least one additional diffraction Peak, expressed in degrees (0,2 u00ba 2Q) selected from the group consisting of Peaks of approximately 4.70, 9.39, 14.10, 15.70, 20,40, 20,42, 21, 42, 22.03, 22.54, 23.62 and 2842； (c) a pattern of x-ray diffraction Peaks characteristic is expressed in degrees (0,2 u00ba approximately 2Q) 17,18 and 20,07 players, and also comprises at least one additional diffraction Peak (0,2 u00ba 2Q (expressed in degrees) about 21.42, 22.54 and 28.42； (d) a P Atr u00f3n x-ray diffraction Peaks characteristic is expressed in degrees (0, 2Q2) to approximately 17, 18.83, 20.07, 21.42, 22.54 and 28.42)； and a Fourier Transform Infrared spectrum in the range of 1.800 600 cm u207b u00b9 substantially as shown in Figure 2； (f) differential Scanning Calorimetry thermogram of a single predominant endothermy has approximately 145,53 u00bac at a Scanning speed of 10C per minute, substantially as shown in Figure 3.1； and (g) of a thermogram differential Scanning Calorimetry that endothermy has only one predominant in the range of 144,01 u00bac to 146,92 u00bac at a Scanning speed of 10C per minute, substantially as shown in Figure 3.2.Reivindicación 1: Una forma cristalina A de 1-(5-(5-(3,5-dicloro-4-fluorofenil)-5-(trifluorometil)-4,5-dihidroisoxazol-3-il)-3H-espiro[azetidin-3,1-isobenzofuran]-1-il)-2-(metilsulfonil)etanona, caracterizada porque exhibe al menos una de las propiedades siguientes: a) un p
