SAHIN UGUR,TÜRECI ÖZLEM,KOSLOWSKI MICHAEL,WALTER KORDEN,WÖLL STEFAN,KREUZBERG MARIA,HUBNER BERND,ERDELJAN MICHAEL,WEICHEL MICHAEL
申请号：
NZ70600412
公开号：
NZ706004A
申请日:
2012.04.20
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is an antibody which comprises an antibody heavy chain and an antibody light chain, wherein the antibody heavy chain comprises the CDR3 sequence of the antibody heavy chain sequence of SEQ ID NO: 36 and the antibody light chain comprises at least one of the CDR sequences of an antibody light chain sequence selected from SEQ ID NOs: 35, 54 and 55 wherein the antibody binds to claudin 6 (CLDN6) associated with the surface of a cell that expresses CLDN6 and does not bind to a CLDN6 mutant on the surface of a cell that expresses said CLDN6 mutant, wherein said CLDN6 mutant comprises an alanine mutation at position 35, 37 or 39 of the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 8
