The fishing tackle box includes a container, a plurality of first guide slots spaced along a first sidewall of the container, a plurality of second guide slots spaced along a second sidewall of the container, and at least one lure holder having an angular panel including a plurality of spaced apart slots for receiving at least one fishing lure with a hook of the fishing lure positioned below the panel and a body of the fishing lure positioned above said panel. At least one first protrusion extends laterally outward from a first sidewall of said lure holder and at least one second protrusion extends laterally outward from a second sidewall of said lure holder to be collectively received by at least one first guide slot and at least one second guide slot. The lure holder may be comprised of different sizes to hold different sizes or numbers of fishing lures.
