治療HCV的方法农业专利-农业专业知识服务系统

发明人:: BERNSTEIN,BARRY,伯斯丁贝瑞,伯斯丁貝瑞,DUTTA,SANDEEP,杜塔珊迪普,LIU,WEI,刘巍,劉巍,PODSADECKI,THOMAS J.,波萨迪奇汤玛士　J,波薩迪奇湯瑪士　J,CAMPBELL,ANDREW L.,坎贝尔安德鲁　L,坎貝爾安德魯　L,MENON,RAJEEV M.,曼诺瑞吉夫　M,曼諾瑞吉夫　M,LIN,CHIH-WEI,林志威,W,波萨迪奇汤玛士 J,波薩迪奇湯瑪士 J,坎贝尔安德鲁 L,坎貝爾安德魯 L,曼诺瑞吉夫 M,曼諾瑞吉夫 M

摘要：: The present invention features interferon- and ribavirin-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the treatment comprises administering at least two direct acting antiviral agents without interferon and ribavirin to a subject with HCV infection, wherein the treatment lasts for 12 weeks, and said at least two direct acting antiviral agents comprise (a) Compound 1 or a pharmaceutically acceptable salt thereof and (b) Compound 2 or a pharmaceutically acceptable salt thereof.本發明之特徵在於用於治療HCV之無干擾素及利巴韋林(ribavirin)之療法。較佳地，該治療係持續較短之治療時間，例如不超過12週。在一個態樣中，該治療包括在無干擾素及利巴韋林之情形下向感染HCV之個體投與至少兩種直接作用性抗病毒劑，其中該治療持續12週，且該至少兩種直接作用性抗病毒劑包含(a)化合物1或其醫藥上可接受之鹽及(b)化合物2或其醫藥上可接受之鹽。