Jon Michael Karpilow,Mark Steven Oberste,Ralph A. Tripp,Stephen M. Tompkins
申请号：
US14765365
公开号：
US20170151322A9
申请日:
2014.02.05
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picomavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection.
