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Cell membrane permeable peptide
专利权人:
東レ株式会社
发明人:
森下 真莉子,高山 幸三,西尾 玲士,井田 伸夫
申请号:
JP2010520082
公开号:
JP5653214B2
申请日:
2010.05.19
申请国别(地区):
JP
年份:
2015
代理人:
摘要:
A cell-penetrating peptide described in any of (A) to (D) below gives cell membrane permeability and further transmucosal absorbability to a physiologically active substance: (A) a peptide having the amino acid sequence represented by SEQ ID NO:1; (B) a peptide having an amino acid sequence which is the same as the amino acid sequence represented by SEQ ID NO:1 except that one or several basic amino acids are substituted, deleted, inserted and/or added, which peptide has cell membrane permeability; (C) a peptide having an amino acid sequence which is the same as the amino acid sequence represented by SEQ ID NO:1 except that 1 to 5 amino acids are substituted, deleted, inserted and/or added, which peptide has cell membrane permeability; (D) a peptide having: an amino acid sequence represented by the reverse sequence of any of (A) to (C); an amino acid sequence which is the same as the amino acid sequence represented by the reverse sequence of (A) except that one or several basic amino acids are substituted, deleted, inserted and/or added; or an amino acid sequence which is the same as the amino acid sequence represented by the reverse sequence of (A) except that 1 to 5 amino acids are substituted, deleted, inserted and/or added; which peptide has cell membrane permeability.
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