An immunogenic composition comprising one or more pneumococcal capsular saccharide conjugates and a protein component comprising H. influenzae-derived protein E and / or PilA
The present invention relates to an immunogenic composition comprising (i) at least one Streptococcus pneumoniae protein; (ii) a Streptococcus pneumoniae capsular saccharide derived from a strain of a targeted serotype of Streptococcus pneumoniae; for use in enhancing antibody-mediated opsonic activity against the targeted serotype of Streptococcus pneumoniae.