Bicyclic compounds derived from dihidroisoquinolin - 1 - One； extraction process； faramceutica Composition and its use for the Treatment or prophylaxis of Chronic Kidney Disease, congestive heart failure, hypertension, Primary Aldosteronism and Cushing's Syndrome.
MOHR, PETER,LIU, YONGFU,AEBI, JOHANNES,AMREIN, KURT,HORNSPERGER, BENOIT,KUHN, BERND,MAERKI, HANS P.,MAYWEG, ALEXANDER V.,ZHOU, MINGWEI,TAN, XUEFEI,CHEN, WENMING,WANG, ZHANGUO
申请号：
CL2014001389
公开号：
CL2014001389A1
申请日:
2014.05.27
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The invention provides novel compounds having the general formula (I)wherein R<；sup>；1<；/sup>；, R<；sup>；2<；/sup>；, R<；sup>；3<；/sup>；, R<；sup>；4<；/sup>；, R<；sup>；5<；/sup>；, R<；sup>；6<；/sup>；, A<；sup>；1<；/sup>；, A<；sup>；2<；/sup>；, A<；sup>；3<；/sup>；, A<；sup>；4<；/sup>；, A<；sup>；5<；/sup>；and n are as described herein, compositions including the compounds and methods of using the compounds.COMPUESTOS HETEROCÍCLICOS, ENTRE LOS QUE SE TIENEN A DERIVADOS DE NAFTIRIDIN-5-ONA, DE ISOQUINOLIN-1-ONA, ISOINDOL-1-ONA, ESPIRO(CICLOPROPANO-1,1’-ISOINDOL)-3’-ONA, PIRROLO[3,4-B]-PIRIDIN-5-ONA； PROCEDIMIENTO DE PREPARACIÓN； COMPOSICIONES FARMACÉUTICAS； ÚTILES PARA TRATAR ENFERMEDADES RENALES CRÓNICAS, FALLO CARDÍACO CONGESTIVO, HIPERTENSIÓN, SÍNDROME DE CUSHING, ENTRE OTROS.
