NOLAN JAMES DEWDNEY,JOSHUA KENNEDY-SMITH,RAMA K. KONDRU,BRADLEY E. LOE,YAN LOU,JOEL MCINTOSH,TIMOTHY D. OWENS,MICHAEL SOTH,ZACHARY KEVIN SWEENEY,JOSHUA PAUL GERGELY TAYGERLY
申请号：
BRPI0907915
公开号：
BRPI0907915A2
申请日:
2009.01.27
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
This application discloses 5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one deriva-tives according to generic Formulae I-III : wherein, variables R, X, Y1, Y2, Y3, Y4, n and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat in-flammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formulae I-III and at least one carrier, diluent or excipient.
