The present invention provides novel dialkyl curcumin derivatives. The dialkyl curcumin derivatives according to the present invention have significant effects in vascularization and tumor growth when compared to curcumin. The dialkyl curcumin derivatives according to the present invention may be used for preventing and curing various vascularization-related diseases and tumor diseases. The dialkyl curcumin derivatives are expressed by chemical formula 1. In the chemical formula 1, R_1 to R_4 are each independently H or C_1-C_5 alkyl； R_5 and R_6 are each independently OH, C_1-C_5 haloalkoxy, polyethyleneoxy, halopolyethyleneoxy, amino, monoalkylamino, dialkylamino, piperidine, piperazine, morpholin, pyrrole, imidazole, benzimidazole, or indole； and R_7 and R_8 are each independently H, OH, or C_1-C_5 alkoxy, wherein the polyethyleneoxy is (ethoxy)_n-OH and n is an integer of 1 to 5.본 발명은 신규한 디알킬 커큐민 유도체를 제공한다. 본 발명의 디알킬 커큐민 유도체는 커큐민과 비교하여 현저한 혈관신생 억제 효과 및 종양성장 억제 효과를 나타낸다. 본 발명의 디알킬 커큐민 유도체는 다양한 혈관신생-관련 질환 및 종양성 질환의 예방 또는 치료에 이용될 수 있다.
