Methods for forming polymeric particles with a predetermined, controlled morphology, and methods for tuning the topology of polymeric particles through modification of components utilized in the formation process are described. An emulsion/condensation technique is used, including a first emulsifier in the aqueous phase and an organic phase that includes first and second solvents, a second emulsifier, and a polymer. The polymer is more soluble in the first solvent than the second solvent, and the second emulsifier is more soluble in the second solvent than the first solvent. Through modification of the relative amounts of the emulsifiers and solvents, particles with either smooth or rough surfaces can be formed. Particles are particularly useful as drug depots with controlled-release profiles.
