Contact thermo-optic structure and its use for noninvasive imaging of the magnitude of histamine-induced superheated subcutaneous reaction in skin allergic reaction, recording device, and allergic reaction diagnostic method
An object of the present invention is a passive planar thermo-optic structure for detecting a region of temperature change on a patient's skin that contains a thermoactive dye. The thermo-optic structure according to the present invention has a laminated structure including a transparent film layer (102), a thermochromic layer (103), a fixed layer (105), an adhesive layer (106), and a protective layer (107). Have At least a part of the surface of the transparent layer (102) forms a screen (102a). The at least one dye in the thermochromic layer exhibits a first color at a higher temperature threshold having a value in the range of 31-37 ° C., and in a temperature range of 0.6 ° C. or higher. The width of the temperature range in which the color is maintained and the color is indefinite is less than 0.3 ° C. A further object of the present invention is the use of the thermo-optical detector according to any one of claims 1 to 20 for the evaluation of the degree of skin allergic reaction. Furthermore, the object of the present invention is to provide a central unit (211), a housing (203) configured to separate the area of the patient's skin from ambient light, and the thermo-optics according to the present invention applied to the patient's skin. A recording apparatus comprising a digital camera (218) for capturing colors displayed by heat displayed on a structure, the ambient temperature measuring means (216) connected to the central unit, and the central unit And a standardized light source for irradiating the thermo-optic structure with a patient skin temperature measuring means (207) connected to the recording device. The method for diagnosing allergy according to the present invention includes the steps of stimulating, measuring, and comparing. The stimulating step includes at least exposing a first region of the patient's skin to a histamine solution, exposing a second region of the patient's skin to a neutral solution, and a third region of the patient's skin. E
