YEANG, CHEN HSIANG,杨振翔,楊振翔,CHEN, MING,陈明,陳明,HSU, HUNG WEI,许紘玮,許紘瑋,MA, GWO CHIN,马国钦,馬國欽,LIN, YI SHING,林怡杏,林怡杏,CHANG, SHUN MIN,张舜闵,張舜閔,CHEN, FU CHAN,陈富钤,陳富鈐,KUO, SHOU JEN,郭守仁,郭守仁
申请号：
TW102131625
公开号：
TW201510224A
申请日:
2013.09.03
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
A non-invasive prenatal detection method on the basis of the whole genome trend score, which is used to detect whether the fetal chromosome is aneuploid and comprises the following steps: establishing a database having the average value mk of the ratio of the length of human chromosome k, obtaining the chromosome data yk of the pregnant woman and the fetus from the blood plasma of the pregnant woman, obtaining P-value from the ratio of the data yk to the value mk, and analyzing the P-value so as to confirm whether the fetal chromosome is aneuploid. Thereby, the comparable data can improve the detection accuracy and enable the pregnant woman to know whether the fetal chromosome is normal.一種以全基因體趨勢記分為基礎之非侵入性產前檢測方法,用以檢測孕婦之子代之體染色體是否為非整倍體,包括下列步驟:建立具有正常人之第k對染色體之長度比率之平均值mk之資料庫;自待測孕婦之血漿取得待測孕婦及其子代之染色體數據yk;以各該yk值分別對於各該mk值之比值而取得p值;分析p值,確定是否有染色體為非整倍體。藉由比較各該p值以及資料庫中之各該p值之大小,增加可對比之數據,以提高檢測之準確性;此外,由於做為比較之數據較多,故即使於妊娠早期,本發明仍具有相當之準確性,以利孕婦早日得知胎兒之染色體是否正常。
