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PROCESS FOR PRODUCTION OF BENZYLOXYPYRROLIDINE DERIVATIVE, AND PROCESS FOR PRODUCTION OF HYDROCHLORIDE SALT POWDER OF OPTICALLY ACTIVE BENZYLOXYPYRROLIDINE DERIVATIVE
专利权人:
发明人:
MORIMOTO MASAO,YAMAKAWA ATSUSHI
申请号:
IN2118/CHENP/2008
公开号:
IN272563B
申请日:
2008.04.29
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
Provided are: a process for production of a benzyloxypyrrolidine derivative in high yield and safety, and a process for production of a hydrochloride powder of a benzyloxypyrrolidine derivative in high yield and safety; the process for production of a benzyloxypyrrolidine derivative expressed by the general formula (2) [Chemical formula 2], in reacting a pyrrolidinol derivative represented by the general formula (1) [Chemical formula 1] with a benzyl halide derivative in the presence of an alkali metal hydroxide, wherein the reaction is carried out in either of the following conditions A or B; condition A: an aprotic polar solvent, and condition B: an aliphatic ether solvent containing a phase transfer catalyst: [Chemical formula 1] [Chemical formula 2]
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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