DÉRIVÉS D'HÉTÉROARYLES BICYCLIQUES EN TANT QUE MODULATEURS MNK1 ET MNK2 ET LEURS UTILISATIONS

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专利权人:

Agency for Science; Technology and Research

发明人:

申请号：

EP17179630.3

公开号：

EP3321268A1

申请日:

2013.04.01

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazpyrimidine compounds) that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of diseases (e.g., proliferative diseases (e.g., cancer), inflammatory diseases, Alzheimer's disease), as well as methods of treating these diseases.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/