One aspect of the present disclosure relates to a method for treating a functional gastrointestinal (GI) disorder in a subject, such as functional dyspepsia or functional constipation. One step of the method can include inserting a therapy delivery device into a vessel of the subject. Next, the therapy delivery device can be advanced to a point substantially adjacent an intraluminal target site of the autonomic nervous system, the central nervous system, or both, that is associated with the functional GI disorder. The therapy delivery device can then be activated to deliver a therapy signal to the intraluminal target site in an amount and for a time sufficient to effect a change in sympathetic and/or parasympathetic activity in the subject and thereby treat the functional GI disorder.
