Triterpenoid compounds of C - 3 cicloalquenilo with Inhibitory activity of the maturation of the HIV virus； Intermediate Compounds, Pharmaceutical Composition and use for treating HIV infection.
SWIDORSKI JACOB,MEANWELL NICHOLAS A.,REGUEIRO-REN ALICIA,SIT SING-YUEN,CHEN JIE,CHEN YAN
申请号：
CL2014002141
公开号：
CL2014002141A1
申请日:
2014.08.13
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-3 cycloalkenyl triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV: wherein X can be a C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6-9 oxaspirocycloalkyl, or C6-9 oxaspirocycloalkenyl ring. These compounds are useful for the treatment of HIV and AIDS.“COMPUESTOS DERIVADOS DE TRIPERTENOIDES CICLOALQUENILO C-3, INHIBIDORES DE LA MADURACIÓN DEL VIRUS DEL VIH； COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENDE； Y SU USO EN EL TRATAMIENTO DEL SIDA； COMPUESTOS INTERMEDIARIOS” PCT
