There are provided various compounds and compositions comprising polyunsaturated fatty acid monoglycerides and derivatives thereof. These compounds and compositions can be useful for increasing the life span of a subject； for increasing the disability-free life expectancy, for slowing down the ageing process of a subject； for increasing the mitochondrial oxphos of a subject； for decreasing the mitochondrial LEAK of a subject； for increasing the mitochondrial RCR or coupling efficiency of a subject； and for optimizing the mitochondrial functions of a subject. These compounds and compositions comprise at least one compound chosen from.
