NOUVEAUX STABILISANTS ET MODULATEURS DU RÉCEPTEUR DE GLP-1

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专利权人:

RECEPTOS; INC.

发明人:

BOEHM, MARCUS, F.,MARTINBOROUGH, ESTHER,MOORJANI, MANISHA,TAMIYA, JUNKO,HUANG, LIMING,FOWLER, THOMAS,NOVAK, ANDREW,MEGHANI, PREMJI,BRAHMACHARY, ENUGURTHI,YEAGER, ADAM, RICHARD

申请号：

EP12793320

公开号：

EP2713722A4

申请日:

2012.05.31

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

Compounds that bind the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, methods of their therapeutic and/or prophylactic use, and methods of their use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor are provided. Certain compounds may have activity as modulators or potentiators with respect to glucagon receptor, GIP receptor, GLP-1 and GLP-2 receptors, and PTH receptor on their own or in the presence of receptor ligands such as GIP(1-42), PTH(1-34), Glucagon(1-29), GLP-2(1-33), GLP-1 (7-36), GLP-1 (9-36), oxyntomodulin and exendin variants.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/