CHONG HAN,KARTHIK NAGAPUDI,PAROMA CHAKRAVARTY,SCOTT SAVAGE,SEAN M. KELLY
申请号：
BR112019013292
公开号：
BR112019013292A2
申请日:
2018.04.26
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
The present invention relates to crystalline polymorphic forms of (s) -2 - ((2 - ((s) -4- (difluoromethyl) -2-oxooxazolidin-3-yl) -5,6-dihydrobenzo [f] imidazo [1,2-d] [1,4] oxazepin-9-yl) amino) propanamide (gdc-0077), which has the structure, formula i: (gdc-0077) or stereoisomers, geometric isomers, tautomers and salts pharmaceutically acceptable forms thereof, and processes for preparing the polymorph forms.a presente invenção refere-se a formas polimorfas cristalinas de (s)-2-((2-((s)-4-(difluorometil)-2-oxooxazolidin-3-il)-5,6-diidrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-il)amino)propanamida (gdc-0077), que tem a estrutura, fórmula i: i (gdc-0077) ou estereoisômeros, isômeros geométricos, tautômeros e sais farmaceuticamente aceitáveis dos mesmos, e processos para preparar as formas polimorfas.
