KIM, DONG-SIK,LEE, MI JUNG,PARK, JAE CHAN,LEE, SUMIN,KWAK, HEECHUN,HWANG, SUNGHO,LIM, HYUNG-KWON,KIM, KISU,PARK, YOUNG SEOUB,JEONG, JUNHONG,CHO, KI JOON
申请号：
CA2977621
公开号：
CA2977621A1
申请日:
2015.12.29
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to an antibody that binds specifically to a tissue factor pathway inhibitor (TFPI), a nucleic acid encoding the antibody, a vector comprising the nucleic acid, a host cell transformed with the vector, a method for producing the antibody, and a pharmaceutical composition for treating hemophilia, which comprises the antibody as an active ingredient. The antibody of the present invention, which binds specifically to TFPI, can activate the extrinsic pathway of blood coagulation by inhibiting TFPI. Thus, the antibody of the present invention can be effectively used for the treatment of antibody-induced hemophilia patients and for the prevention of blood coagulation disease in hemophilia-A or hemophilia-B patients.
