THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
WENDER, PAUL,QUIROZ, RYAN,HO, STEPHEN,SHIMIZU, AKIRA,RYCKBOSCH, STEVEN,STEVENS, MATTHEW C.,JEFFREYS, MATTHEW S.,HARDMAN, CLAYTON,SLOANE, JACK
申请号：
CA3038532
公开号：
CA3038532A1
申请日:
2017.09.28
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Methods for preparing a variety of bryostatin compounds are provided. The subject methods provide for preparation of bryostatin 1 in multi-gram quantities in a low and unprecedented number of convergent synthetic steps from commercially available materials. The subject methods are scalable with low estimated material costs and can provide enough material to meet clinical needs. Also provided are a variety of bryostatin analog compounds, and prodrug forms thereof, which are synthetically accessible via the subject methods and pharmaceutical compositions including the same.
