Rimas Orentas,Dina Schneider,Waleed M. Haso,Stefan Miltenyi,Boro Dropulic
申请号：
US16078269
公开号：
US20190241641A1
申请日:
2017.09.01
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Novel therapeutic immunotherapy compositions comprising at least two vectors, each vector encoding a functional CAR, whereby the combination of vectors results in the expression of two or more non-identical binding domains, wherein each vector encoded binding domain(s) are covalently linked to a transmembrane domain and one or more non-identical intracellular signaling motifs are provided herein as well as are methods of use of same in a patient-specific immunotherapy that can be used to treat cancers and other diseases and conditions.
