Next general formula (ii) it is the GPR119 operation glaze, _(expression in, Ar C alkyl sulfonyl basis such as substituent with displacement do be good phenyl group or pyridyl basis display As for A (CH), O and the like displaying, As for B (CH) and the like displaying, U, V each as for one with N, as for another side it is CR whether, or U and V are N together, As for X and Y, displaying the alkylene of the carbon atom several 1 - 3 which is good being displacement with the substituent, As for R C alkyl group and the like displaying,And, R and R display the hydrogen atom and the halogen atom etc.)So you use the annular amine derivative which is displayed as the diabetes curative medicine.GPR119作動薬である次の一般式(II)、(式中、Ar0はC1-8アルキルスルホニル基等の置換基で置換されていても良いフェニル基又はピリジル基を表しA0は(CH2)p、O等を表し、B0は(CH2)q等を表し、U0,V0の何れか1つはNで、他方はCR26であるか、又はU0及びV0が共にNであり、X0及びY0は、置換基で置換されていても良い炭素原子数1~3のアルキレンを表し、R23はC1-8アルキル基等を表し、そして、R21及びR22は水素原子、ハロゲン原子等を表す。)で表される環状アミン誘導体を糖尿病治療薬として使用する。
