Paul Van Eerdewegh;Jason Simon;Sunil D. Pandit;Kristina Allen;Randall D. Little;Richard G. Del Mastro;Josée Dupuis;Tim Keith
发明人:
Tim Keith,Randall D. Little,Paul Van Eerdewegh,Josée Dupuis,Richard G. Del Mastro,Jason Simon,Kristina Allen,Sunil D. Pandit
申请号：
US13341457
公开号：
US20120100146A1
申请日:
2011.12.30
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.
