最佳化之跨物種特異性雙特異性單鏈抗體構築體农业专利-农业学术服务平台

发明人:: RATTEL, BENNO,拉托　班诺,拉托　班諾,FRIEDRICH, MATTHIAS,弗瑞德里奇　马修斯,弗瑞德里奇　馬修斯,KUFER, PETER,库佛　彼德,庫佛　彼德,HOFFMANN, PATRICK,霍夫曼　派翠克,RAUM, TOBIAS,瑞乌　托拜耳斯,瑞烏　托拜耳斯,MUNZ, MARKUS,孟兹　马克斯,孟茲　馬克斯,HERRMANN, INES,赫曼恩　,拉托班诺,拉托班諾,弗瑞德里奇马修斯,弗瑞德里奇馬修斯,库佛彼德,庫佛彼德,霍夫曼派翠克,瑞乌托拜耳斯,瑞烏托拜耳斯,孟兹马克斯,孟茲馬克斯,赫曼恩

摘要：: The present invention provides to a bispecific single chain antibody construct binding to a target cell surface antigen via a first binding domain and to the T cell surface antigen CD3 via a second binding domain, wherein serum albumin is fused to the C-terminus of the antibody construct. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.本發明提供一種經由第一結合域結合至靶細胞表面抗原及經由第二結合域結合至T細胞表面抗原CD3之雙特異性單鏈抗體構築體，其中血清白蛋白係融合至該抗體構築體之C端。此外，本發明提供編碼該抗體構築體之聚核苷酸、包括該聚核苷酸之載體及經該載體轉形或轉染之宿主細胞。此外，本發明提供一種用於製造本發明之抗體構築體之方法；該抗體構築體之醫學應用及包括該抗體構築體之套組。