GRASSO LUIGI,SPIDEL JARED,KLINE JAMES BRADFORD,ALBONE EARL
申请号：
IN201737044504
公开号：
IN201737044504A
申请日:
2017.12.12
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
Provided herein are methods for generating conjugated immunoglobulins the method comprising: decapping a cysteine at amino acid position 80 (Cys80) in a light chain variable region of an immunoglobulin wherein the immunoglobulin comprises a heavy chain variable region and the light chain variable region and conjugating a thiol reactive compound to the Cys80 wherein the thiol reactive compound comprises a thiol reactive group. Antigen binding molecules and methods for generating the same immunoglobulins as well as nucleic acid molecules encoding the immunoglobulins and host cells comprising the nucleic acid molecules conjugated immunoglobulins and light chain variable regions for use in a conjugated immunoglobulin are also provided.
