Ananth Annapragada,Russell M. Lebovitz,Ketankumar B. Ghaghada
申请号：
US13256672
公开号：
US20120003159A1
申请日:
2010.03.18
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Examples of compositions of liposomes and methods of making the same containing high concentrations of contrast-enhancing agents for computed tomography are provided. Example compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes stable, that is, resistant to leakage of the contrast-enhancing agents, including the extrusion of the liposomes at high pressures and at high flow rates per total pore area of the extrusion filters.
