THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY
发明人:
SAVARINO, STEPHEN J.
申请号：
CA2592444
公开号：
CA2592444C
申请日:
2006.01.10
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The inventive subject matter relates to the methods for the induction ofimmunity and prevention of diarrhea resulting from Escherichia coli. Theinventive subject matter also relates to the use Escherichia coli adhesins asimmunogens and to the construction of conformationally stability and proteaseresistant Escherichia coli adhesin constructs useful for inducing immunity toEscherichia coli pathogenic bacteria. The methods provide for the induction ofB-cell mediated immunity and for the induction of antibody capable ofinhibiting the adherence and colonization of Escherichia.coli, including.enterotoxigenic Escherichia coli, to human cells.
