<；P>；PROBLEM TO BE SOLVED: To provide a safe and efficient IVR-treating agent without using an anti-tumor agent damaging normal cells. <；P>；SOLUTION: This treating agent having an apoptosis-inducing activity and containing at least one of 1 kind of cell propagation-inhibitor among bisphosphonate derivative, vitamin K or their derivative, and 1 kind or &ge；2 kinds of immuno-activating agents such as an activated lymphocyte or dead microbial cells such as an AHCC, hemolytic streptococcus or their extracts, Maruyama vaccine, fungi such as an Agaricus blasei, etc., and their extracts, etc., as a main active component is useful for obtaining a big effect in the treatment of malignant tumors by administering it, or further preferably by using it together with the IVR treatment. <；P>；COPYRIGHT: (C)2005,JPO&NCIPI
