Theobald, Pamela Joan,Best, Desmond John,Mak, Sing Yeung,Orlek, Barry Sidney,Rassias, Geracimos
申请号：
AU2008294708
公开号：
AU2008294708B2
申请日:
2008.09.04
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention relates to 1-(1-methylethyl)-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine (Formula) or a pharmaceutically acceptable salt thereof, in particular the hydrochloride salt thereof and crystalline forms of the hydrochloride salt to processes for the preparation of the compound or its salt to compositions containing it and to its use in the treatment or prophylaxis of neurological or psychiatric diseases, such as cognitive impairment, fatigue or a sleep disorder, for example in a mammal such as a human. The compound or a salt thereof has affinity for and is an antagonist and/or inverse agonist of the histamine H3 receptor.
