In part, the disclosure relates to systems and methods to assess stent/scaffold expansion in a vessel on an expedited time scale after stent/scaffold placement and expansion. In one embodiment, the method generates a first representation of a stented segment of the blood vessel indicative of a level of stent expansion； determines using the detected stent struts, a first end of the stent and a second end of the stent； and generate a second representation of the segment of the blood vessel by interpolating a lumen profile using an offset distance from the first end and the second end.
