A syringe is provided. The syringe includes a syringe barrel including an open proximal end, a closed distal end, and a sidewall extending therebetween. The syringe also includes: a plunger having an annular sidewall configured to seal against an interior surface of the sidewall of the syringe barrel, the plunger being configured to move through the syringe barrel in proximal and distal directions； a pump in fluid communication with an interior volume of the syringe barrel, the pump being configured to draw fluid from the syringe barrel； and a nozzle including a lumen in fluid communication with the pump and configured to receive fluid drawn from the syringe barrel by the pump and to expel the fluid through a distal end of the lumen. The pump can be a valve-less piston pump.
