599143 Disclosed is a multi-particulate digestive enzyme composition comprising enterically coated digestive enzyme-containing beads, and uncoated digestive enzyme containing beads, wherein: the enterically coated digestive enzyme-containing beads comprise a core and an enteric coating disposed over the core, wherein the core comprises a therapeutically effective amount of lipase, and the enteric coating comprises an enteric polymer； and the uncoated digestive enzyme-containing beads comprise a therapeutically effective amount of protease, and is substantially free of an enteric polymer coating； wherein the digestive enzymes comprise lipase and protease, and the ratio of lipase and protease activities in the enterically coated digestive enzyme-containing beads to the lipase and protease activities in the uncoated digestive enzyme-containing beads ranges from about 5:95 to about 50:50.
