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Cross-species-specific PSMAxCD3 Bispecific Single Chain Antibody
专利权人:
Amgen Research (Munich) GmbH
发明人:
Kufer, Peter,Raum, Tobias,Hoffmann, Patrick,Klinger, Matthais,Rau, Doris,Mangold, Susan,Lutterbuese, Ralf,Kischel, Roman,Schaller, Evelyne,Hausmann, Susanne,Fluhr, Petra,Steiger, Carola
申请号:
AU2014201850
公开号:
AU2014201850A1
申请日:
2014.03.31
申请国别(地区):
AU
年份:
2014
代理人:
摘要:
#$%^&*AU2014201850A120140417.pdf#####ABSTRACT The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an 5 amino acid sequence comprised in the group consisting of SEQ ID Nos 2, 4, 6 and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical 10 compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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