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Means for the inhibition of anti-beta1-adrenergic receptor antibodies
专利权人:
Julius-Maximilians-Universitat Wurzburg
发明人:
Palm, Dieter,Lohse, Martin J.,Jahns, Valerie,Jahns, Roland
申请号:
AU2006228664
公开号:
AU2006228664B2
申请日:
2006.03.31
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The present invention is related to a peptide selected from the group comprising a) a cyclic peptide of formula (I): Cyclo(AIa-x-x-x-x-x-x-x-x-x-Cys-x-x-x-Pro-x-Cys-Cys-xk-GIn), (I) whereby k is any integer from 0 to 6, preferably any integer from 1 to 6, more preferably k = 6; b) a cyclic peptide of formula (II): Cyclo(Ala-x-x-Trp-x-x-Gly-x-Phe-x-Cys-xh-Gln), (II) whereby h is any integer from 0 to 2, preferably 1 or 2; c) a cyclic peptide of formula (III): Cyclo(AIa-x-x-x-x-x-x-x-x-x-Cys-xj-Cys-x-x-x-Pro-x-Cys-Cys-xi-Gln); (HI) whereby j is any integer from 0 to 4, preferably j = 4; whereby i is any integer from 0 to 6, preferably any integer from 1 to 6, more preferably i - 6; and d) a peptide of formula (IV) : Ala-xl-Cys-xm-Cys-x-x-x-Pro-x-Cys-Cys-xn-Gln, (IV) whereby 1 is any integer from 0 to 9, preferably any integer from 1 to 9, more preferably n = 9; whereby m is any integer from 0 to 4, preferably any integer from 1 to 4, more preferably m = 4; whereby n is any integer from O to 6, preferably any integer from 1 to 6, more preferably n = 6; whereby x is any amino acid, preferably any naturally occurring amino acid, more preferably any naturally occurring L-amino acid.
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