Disclosed is an isolated monoclonal antibody or antigen-binding fragment thereof that specifically binds ErbB3, wherein the antibody or antigen-binding fragment interacts with amino acids 345-367 of SEQ ID NO:498, amino acids 423-439 of SEQ ID NO:498 and amino acids 451-463 of SEQ ID NO:498, as determined by hydrogen/deuterium exchange, wherein the sequences are as defined in the complete specification. Also disclosed is use of the antibody for inhibiting or attenuating tumour growth.本發明提供結合至ErbB3之抗體以及使用該等抗體的方法。依據本發明的某些實施方案,該等抗體爲結合至人類ErbB3的完全人類抗體。在某些實施方案中,本發明抗體阻斷ErbB3與諸如神經調節蛋白1(neuregulin1)的ErbB3配體的相互作用。本發明抗體可用於治療多種癌症。
