Zoltán Greff,Zoltán Varga,György Kéri,Gábor Németh,László Örfi,Csaba Szántai Kis
申请号：
US13517120
公开号：
US09040529B2
申请日:
2010.12.17
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention relates compounds of general formula (I) and pharmaceutically acceptable salts and solvates thereof whereinR1 is halogen, vinylene-aryl, substituted aryl, heteroaryl or a benzo[1,3]dioxolil group,W is a group of formula —NH—SO2—R2 or heteroaryl group or NHR3 group where R3 is hydrogen or heteroaryl and n is 1, 2, 3 or 4.Furthermore, the present invention is directed to pharmaceutical composition containing at least one compound of general formula (I) and/or pharmaceutically acceptable salts or solvates thereof and for the use of them for the preparation of pharmaceutical compositions for the prophylaxis and/or the treatment of protein kinase related, especially CDK9-related diseases e.g. cell proliferative disease, infectious disease, pain, cardiovascular disease and inflammation.
