A filling device (300) for breaking at least one ampoule (700) and for filling a syringe (600) from the ampoule is disclosed. The filling device has a base body (310), which delimits at least one hollow space (315). At the distal end, each hollow space has a removal opening, which is connected to a port (313) for the multi-use syringe. A breaking unit is designed to break the ampoule located in the hollow space. In some embodiments, the breaking unit comprises an actuating element, which is used to slide at least two ampoules onto a wedge-shaped structure, respectively, by way of a single actuating movement in the longitudinal direction, in order to apply a lateral force on the tips of the ampoules. In other embodiments, the breaking unit comprises an actuating element (320) that can be inserted in the transverse direction and acts directly on the tips of the ampoules in order to shatter or shear them off.
