BRINKMANN, ULRICH,DENGL, STEFAN,GEORGES, GUY,HOFFMANN, EIKE,MAYER, KLAUS,BORMANN, FELIX
申请号：
CA3078157
公开号：
CA3078157A1
申请日:
2018.10.19
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Herein is reported a method for the generation of multispecific antibodies by a half- antibody exchange reaction between two 2/3-IgGs destabilized in one half by asymmetric perturbing mutations fostering the generation of correctly assemble full length bispecific antibodies. The method can be performed in the absence of reducing agents and does not require hinge region disulfide bonds in the starting 2/3-IgGs.
