A drug in adhesive (DIA) type transdermal patch for sustaining controlled drug/active release for the treatment of acetylcholine agonist (±) anatoxin-A poisoning involving a select combination of drug/active composed of eserine and pralidoxime chloride (2-PAM) which would facilitate controlled sustained release of the drug/active The DIA matrix type transdermal patch can be generally thin, circular, smooth, uniform and flexible in nature, and can be applied to "dermal surface" including (i) intact , unbroken skin (ii) skin which is open e.g. lacerated,burned,blistered and the like and (iii) mucosal tissue. Advantageously, the DIA matrix type transdermal patch against acetylcholine agonist neutotoxin poisoning is found to be effective as non-invasive type transdermal drug sustained release delivery systems for a period of upto about 72 hours. Fig. 1
