Der-Yang Lee;Harry S. Sowden;Shun-Por Li;David Wynn;Martin Thomas
发明人:
Harry S. Sowden,David Wynn,Shun-Por Li,Der-Yang Lee,Martin Thomas
申请号：
US10476530
公开号：
US08545887B2
申请日:
2002.09.28
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A dosage form comprises: (a) at least one active ingredient: (b) a core having a first surface portion upon which resides a first coating and a second surface portion which is substantially free of the first coating； and (c) a shell which resides upon at least a portion of the second surface portion, wherein the shell comprises a different material from the first coating. In another embodiment, the dosage form comprises: (a) at least one active ingredient； (b) a core comprising a center portion having an exterior surface and an annular portion having an exterior surface and an interior surface, wherein the annular portion interior surface is in contact with at least a portion of the center portion exterior surface, and a coating resides on at least a portion of the annular portion exterior surface； and (c) a shell which resides upon at least a portion of the exterior surface of the center portion, wherein the shell comprises a different material than the impermeable coating. In another embodiment, the dosage form comprises: (a) at least one active ingredient； (b) a core having an outer surface and a cavity which extends at least partially through the core such that the core outer surface has at least a first opening therein； (c) a first coating which resides on at least a portion of the core outer surface, wherein the first shell portion comprises a different material from the first coating； and (d) a first shell portion which is adjacent to the first opening and covers at least the first opening.
