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ROR1(NTRKR1)specific chimeric antigen receptors for cancer immunotherapy
专利权人:
Cellectis
发明人:
Schiffer-Mannioui, Cecile
申请号:
AU2015295349
公开号:
AU2015295349A1
申请日:
2015.07.29
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a ROR1 monoclonal antibody, conferring specific immunity against ROR1 positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas and leukemia, and for solid tumors such as breast, colon, lung, and kidney tumors
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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