BERBERICH DAVID W,JIANG TAO,BRANDT JOHN,CANTRELL GARY L,LIAO SUBO,WANG PETER X,TRAWICK BOBBY N
申请号：
NZ61165108
公开号：
NZ611651A
申请日:
2008.12.17
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed herein are sinomenine derivatives of formula (I), wherein the variables are as defined in the specification. Also disclosed is a process encompassing synthetic routes for the production of (+)-sinomenine derivatives and their intermediates. Sinomenine is an alkaloid isolated from the root of Sinomenium acutum, which is reported to possess anti-inflammatory, analgesic, blood pressure lowering, and anti-arrhythmia activities. Both the isolated molecule and the S. acutum plant have been used clinically in China for the treatment of rheumatoid arthritis.
