A disposable medical device with a lighting effect has a body and a light assembly. The body has an inspection portion, a grip portion, and a placement portion. The light assembly is detachably connected to the body and has an outer casing, a lighting module, and a power supply module. The outer casing is detachably connected to the placement portion of the body, and has a chamber, a communicating hole, and a through hole. The lighting module is deposited in the outer casing and has a luminous body and a pressing-conductive arm. The pressing-conductive arm is swingably deposited in the outer casing, is selectively and electrically connected to the luminous body, and has an abutting portion and a conductive portion. The power supply module is deposited in the chamber, and is selectively and electrically connected to the lighting module and the conductive portion of the pressing-conductive arm.