An extracorporeal therapy system includes: (i) a dialysis fluid circuit including dialysis fluid preparation structure configured to prepare a dialysis fluid for an extracorporeal therapy treatment； (ii) a blood circuit including a blood filter for use during the extracorporeal therapy treatment； (iii) a blood pump operable to pump blood through the blood circuit and blood filter； and (iv) a control unit operable with the dialysis fluid preparation structure and the blood pump, the control unit programmed to prepare a gas generation fluid different than the dialysis fluid for the extracorporeal therapy treatment, wherein the gas generation fluid generates carbon dioxide ("CO
