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VACCINE COMPOSITION AGAINST A MALIGNANT TUMOR
专利权人:
ИНК. (JP);ИНТЕРНЕШНЛ ИНСТИТЬЮТ ОФ КЭНСЕР ИММУНОЛОДЖИ
发明人:
СУГИЯМА Харуо (JP)
申请号:
RU2010127298/15
公开号:
RU2010127298A
申请日:
2008.12.05
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. Vaccine composition against a malignant tumor for positive for human leukocyte antigen (HLA) -A * 0206 individuals, containing the protein product of the tumor suppressor WT1 protein or its incomplete peptide. ! 2. The composition according to claim 1, where the protein product of the tumor suppressor WT1 gene is a protein in accordance with the following (a) or (b):! (a) a protein consisting of the amino acid sequence of SEQ ID NO: 1, or! (b) a protein consisting of an amino acid sequence with a deletion, substitution or addition of one to several amino acids in the amino acid sequence (a), each of which is immunogenic in HLA-A * 0206 positive individuals. ! 3. The composition according to claim 1, where the incomplete peptide is! peptide WT1187: Ser Leu Gly Glu Gln Gln Tyr Ser Val (SEQ ID NO: 2),! peptide WT1126: Arg Met Phe Pro Asn Ala Pro Tyr Leu (SEQ ID NO: 3),! peptide WT1187P1F: Phe Leu Gly Glu Gln Gln Tyr Ser Val (SEQ ID NO: 11),! peptide WT1187P2M: Ser Met Gly Glu Gln Gln Tyr Ser Val (SEQ ID NO: 16),! peptide WT1187P3M: Ser Leu Met Glu Gln Gln Tyr Ser Val (SEQ ID NO: 20),! peptide WT1126P1F: Phe Met Phe Pro Asn Ala Pro Tyr Leu (SEQ ID NO: 34),! peptide WT1126P2L: Arg Leu Phe Pro Asn Ala Pro Tyr Leu (SEQ ID NO: 39),! WT1126P3M peptide: Arg Met Met Pro Asn Ala Pro Tyr Leu (SEQ ID NO: 46) or! peptide WT1126P9V: Arg Met Phe Pro Asn Ala Pro Tyr Val (SEQ ID NO: 49). ! 4. The composition according to claim 1 or 2, additionally containing an adjuvant. ! 5. A malignant tumor vaccine composition for HLA-A * 0206 positive individuals, containing DNA encoding the WT1 protein suppressor gene product protein or an incomplete peptide thereof. ! 6. A malignant tumor vaccine composition for HLA-A * 0206 positive individuals, containing RNA encoding the WT1 protein suppressor gene product protein or an incomplete peptide thereof. ! 7. Method in1. Вакцинная композиция против злокачественной опухоли для положительных по лейкоцитарному антигену человека (HLA)-A*0206 индивиду
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